Study supports concept of 2-stage H5N1 vaccination

first_imgOct 13, 2006 (CIDRAP News) – The human immune system may respond better to a vaccine for a new strain of H5N1 avian influenza if it is prepared in advance with a vaccine based on an existing H5N1 strain, the preliminary results of a government-sponsored study suggest.In the study, 37 people who had received an H5N1 vaccine in 1998 were recently given another H5N1 vaccine based on a 2004 strain. They had a much stronger immune response than did another group who received only the newer vaccine, according to the National Institute of Allergy and Infectious Diseases (NIAID).”These preliminary findings need to be confirmed in larger studies, but they offer the intriguing possibility that pre-pandemic priming with existing H5N1 vaccines may boost the immune response to a different H5N1 vaccine tailor-made years later to thwart an emerging pandemic,” NIAID Director Dr. Anthony S. Fauci commented in a news release.Researchers from the University of Rochester were scheduled to present a preliminary report of their findings today at the Infectious Diseases Society of America’s annual meeting in Toronto, the NIAID reported.When a pandemic flu strain emerges, it will probably take several months to develop a vaccine to match it, and more than one dose will probably be necessary to generate protective immunity, the NIAID said. But providing two doses would be logistically difficult, so researchers have been looking for other strategies. One proposed option is to vaccinate people in advance with a related vaccine in the hope that only one dose of the pandemic vaccine would be necessary.After the first human cases of H5N1 illness occurred in Hong Kong in 1997, the NIAID funded the production of an experimental vaccine based on the Hong Kong virus and tested it in a clinical trial at the University of Rochester in 1998. The researchers found 37 people from that trial who were willing to take part in the new study. Participants in the earlier trial had received two doses of the vaccine.This year, the 37 volunteers were vaccinated with one 90-microgram (mcg) dose of an H5N1 vaccine based on a strain that circulated in Vietnam in 2004, according to a study abstract provided by the University of Rochester. The vaccine is made by Sanofi Pasteur and is the one the US government is currently stockpiling in the face of the pandemic threat, according to Fauci. (That vaccine has shown only modest benefits in trials so far, with about half of vaccinees showing a good immune response after two 90-mcg doses, or about a dozen times the dosage used in seasonal flu vaccine.)The previously vaccinated volunteers had a mean antibody titer (measured by hemagglutination inhibition) of 64.0, with 70% of them achieving a titer of at least 40, according to the study abstract. These findings were compared with results in some volunteers who received 90 mcg of the Sanofi vaccine in a previous study and had never had H5N1 vaccine before. These volunteers had a mean antibody titer of 27.1 after one dose, and only 29% had a titer of at least 40.”We studied a relatively small group, so that certainly, this issue needs to be studied more thoroughly in a larger group of people,” senior author Dr. John J. Treanor, MD, commented in a University of Rochester news release.If further studies confirm the findings, pandemic response planners might consider giving a “priming” shot to key personnel, such as healthcare workers, said Treanor, who directs the university’s Vaccine and Treatment Evaluation Unit.Fauci told CIDRAP News today, “The data look very encouraging, but the number of people [in the study] is relatively small.””These data add some scientific credence to the concept that there may be some benefit to priming someone with a potential pandemic strain even though the actual pandemic strain might be somewhat different,” he said. “It informs the debate to allow you to have a more scientific basis if you’re considering priming.”See also:NIH news releasehttp://www.niaid.nih.gov/news/newsreleases/2006/Pages/IDSA.aspxUniversity of Rochester news releasehttp://www.eurekalert.org/pub_releases/2006-10/uorm-ebs101206.phplast_img read more

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Three men slashed and killed in Barbados following domestic disputes

first_img 56 Views   no discussions NewsRegional Three men slashed and killed in Barbados following domestic disputes by: – March 27, 2012 Share Tweet Sharecenter_img Share Sharing is caring! BRIDGETOWN, Barbados – Three men were stabbed to death in less than 24 hours following separate domestic disputes incidents between Friday afternoon and the early hours of Saturday morning.Barbados police question two, and remain on the hunt for a third suspect.And, police are today questioning a woman and a man in connection with two of those incidents, and are looking for a third man in connection with the last incident.Dead are Mr. Sylvan Trotman, 55, of Sanford, St. Philip, Mr. Macolm Husbands, 45, of 2nd Avenue, Welchman Hall, St. Thomas and Mr. James Jackman, 45, of Greenfields, The City.The bloody period started on Friday afternoon when Mr. Trotman received multiple stab wounds on Friday around 4 p.m. following an altercation with a relative. He was rushed to the Queen Elizabeth Hospital where he later died. The relative, a man, is said to be in police custody.By 9 p.m. police were called to the murder scene of Mr. Jackman who died following a domestic dispute with his female friend at his home. That woman is also now in police custody assisting with that investigation.And, by 5 a.m. lawmen were looking at the body of Mr. Husbands whose throat was cut by an assailant after he opened the door of his home to see who threw a rock through his window. His female friend who was in the house at the time was also attacked. Their attacker fled the scene but has since been apprehended by police.Investigations into the three murders are continuing. Caribbean 360 Newslast_img read more

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Hancock’s Bagley overcomes obstacles to claim international free-throw title

first_img Bio Ellsworth runners compete in virtual Boston Marathon – September 16, 2020 Latest posts by Mike Mandell (see all) Latest Posts Mike MandellMike Mandell is the sports editor at The Ellsworth American and Mount Desert Islander. He began working for The American in August 2016. You can reach him via email at mmandell@ellsworthamerican.com.center_img Hospice volunteers help families navigate grief and find hope – September 12, 2020 HANCOCK — For the past year and a half, nothing has stopped Kaylee Bagley’s mission to improve.From making less than one-third of her attempts in her first free-throw shooting competition to dealing with illnesses on two separate competition days, Bagley has faced her share of obstacles. Despite everything, the 10-year-old Hancock native has continued her drive toward becoming one of America’s best young free-throw shooters.That journey saw a rewarding conclusion Saturday as she received the international title for her age group in the Knights of Columbus Free Throw Championship. As a reward for beating out thousands of other girls from the United States and Canada, Bagley received a glass trophy commemorating her achievement at a ceremony in Brewer.“She’s come a long way from when she got started,” said Kaylee’s mother, Christine. “She loves basketball, and she’s just been so determined and stuck with it no matter what.”This is placeholder textThis is placeholder textBagley’s first competition came as an 8-year-old 18 months ago. In her first competition at the local level, she made just 7 of 25 from the free-throw line.Instead of giving up, Kaylee set an ultimate goal for herself. As she and her parents walked toward the car to go home that day, Kaylee told them her goal was to make it to nationals.“I knew I could make more shots every day if I tried,” Kaylee said. “I knew I could do it if I worked harder and just kept practicing.”Kaylee said she practiced her free throws for an hour and a half in the buildup to the competition. Her parents made trips with her each day to the Hancock Grammar School gymnasium, where Kaylee would practice free-throw shooting for an hour and a half.Kaylee Bagley poses with her trophy and medal after winning the state’s Elks Free Throw Hoop Shoot for the 8-9 age group Jan. 28, 2017, in Bath. Bagley, who made 18 of 25 free throws at the 2017 Elks event, improved her total to 23 of 25 at this year’s Knights of Columbus state championships to win the international title. FILE PHOTOEach day, Kaylee got better and better. Then, on Jan. 28, 2017, she made 18 of her 25 shots to win the 8-9 age group at the state’s Elks Free Throw Hoop Shoot in Bath.“It was amazing how much better she got in just a short amount of time,” said Kaylee’s father, Shawn. “She went in with her goal of how many she wanted to make, and she kept increasing them every day.”In 2018, though, Kaylee was faced with some untimely setbacks. When a stomach bug forced her to forego this year’s Elks competition, she was forced to compete in the Knights of Columbus event instead.Yet the day before the Knights of Columbus district championships, Kaylee fell sick once again. Fortunately, an impending snowstorm that was set to hit eastern Maine the next day forced tournament officials to postpone the event.“I remember picking her up from school that day, and I said, ‘Honey, they postponed it,’” Christine said. “All of the sudden, I see tears of joy on her face and a look that said, ‘Thank God.’”Another complicating factor was that the free-throw lines used in the Knights of Columbus competition were slightly farther back than those used in the Elks competition. It also didn’t require other contestants and spectators to sit in complete silence as competitors were shooting.To get used to the new distance, Kaylee used a tape measure to adjust the distance of the shot she had to make. Her parents and brother, Jacob, helped her adjust to the noise change by making animal sounds and creating other distractions in the background as she shot.After strong showings at the district championships and regional championships, Kaylee made 23 of 25 at the state championship to claim the Maine title. Her score there was compared to others from the same age group in the United States and Canada to determine the international champion, and after the final results were tallied over the next several weeks, Kaylee was the winner.“The first week of May, we got a letter from the Knights of Columbus corporate office in Connecticut saying she had placed the highest in her age group,” Shawn said. “She’s wanted Saturday night to come ever since.”Although Kaylee has been playing basketball since before she was kindergarten, her interest in free-throw competitions came from watching Jacob take part in them. Although she wasn’t old enough to compete when Jacob, now 11, became eligible, seeing him compete inspired her to do so herself.Despite the fact that Kaylee and Jacob have what Christine called a “rivalry” between the two of them in the sport, Jacob is also his sister’s biggest fan. When Kaylee won her first competition at Elks last year, Jacob was there applauding his sister and yelling her name in celebration. His display was so exuberant that a committee member later recognized him for his passion.“He came over and pointed to Jacob, and he said, ‘You, young man, are the reason why we do this,’” Christine said. “As a parent, to see both of them recognized like that was very special.”As for Kaylee, she will continue to play on her AAU team, Black Bear North, as well as in local recreational leagues. If her massive improvement at the free-throw line is any indication of how far she can go, the sky is the limit.“Your kids can surprise you in amazing ways,” Christine said. “When she made those seven shots the first time, we never thought she would be here then. She proved everybody wrong.” MPA approves golf, XC, field hockey, soccer; football, volleyball moved to spring – September 10, 2020last_img read more

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Shohei Ohtani, Mike Trout lead Angels to series victory over Mariners

first_imgWith two outs, Young reached on third strike that got past catcher Mike Zunino. Rivera then doubled home Young. Ian Kinsler walked. Trout followed with a three-run homer, putting the game away.Trout has been on a hot streak, even by his standard, with 11 hits in his last 19 at-bats, including six extra-base hits.“I’m getting pitches and not missing them,” Trout said. “Getting my foot down. The timing is good right now. I’m seeing pitches and putting good at-bats together.”Trout also helped Ohtani out of a potential jam with a brilliant throw in the fifth. Ben Gamel had tried to go from first to third on a single up the middle, but Trout made a strong throw to nail him. Gamel was initially called safe, but the replay showed he slid off the base. Jose Suarez’s rocky start sinks Angels in loss to Astros Ohtani sliced though the Mariners lineup without much trouble. He gave up just four singles in the first six innings, before a hiccup in the seventh. He gave up Ryon Healy’s two-run homer and then a walk, ending his day.“He was fantastic,” catcher René Rivera said. “All his pitches were working, not only his splitter, but the slider was nasty. The curveball was good. He mixed everything up to get those hitters off balance. He did a great job.”Ohtani said he was even pleasantly surprised that he was so sharp, considering he hadn’t pitched since April 24. His start was pushed back because of a mild ankle sprain suffered running the bases.“It was a lot better than I expected,” he said. “It felt like a normal day’s rest.”Seattle’s Kyle Seager, who had two of the hits against Ohtani, was impressed with his first look: “I thought his stuff was real. He definitely throws hard, had the good splitter. He was throwing some slower curves and it seemed like he had his slider working really well today too.”Ohtani said his only frustration that was that he didn’t finish well, allowing the two-run homer in the seventh.“One big difference from Japan to here is everyone can hit home runs, from 1 to 9, so I just need to stay sharp,” he said.By the time the Mariners got to Ohtani, the Angels had a 6-0 lead, thanks to a pair of second-inning homers by Zack Cozart and Chris Young and a sudden rally in the sixth.Related Articles Angels’ Shohei Ohtani spending downtime working in outfield Clippers, Mavericks brace for the unknown in Game 4 Mike Trout, with bat and glove, helps Angels end losing streak center_img PreviousLos Angeles Angels’ Chris Young is greeted in the dugout after he hit a solo home run during the second inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani throws against the Seattle Mariners in the third inning of a baseball game, Sunday, May 6, 2018, at Safeco Field in Seattle. (AP Photo/Ted S. Warren) SoundThe gallery will resume insecondsLos Angeles Angels’ Zack Cozart heads to first base after hitting a double during the fourth inning of a baseball game against the Seattle Mariners, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels’ Zack Cozart is greeted in the dugout after he hit a solo home run in the second inning of a baseball game against the Seattle Mariners, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani throws against the Seattle Mariners in the third inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Seattle Mariners starting pitcher Felix Hernandez stands on the mound as Los Angeles Angels’ Chris Young rounds the bases after hitting a solo home run in the second inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Seattle Mariners starting pitcher Felix Hernandez throws against the Los Angeles Angels in the second inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani throws against the Seattle Mariners in the second inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani throws against the Seattle Mariners in the second inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani throws against the Seattle Mariners in the first inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani throws against the Seattle Mariners in the first inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Fans hold cards with the name of Los Angeles Angels pitcher Shohei Ohtani as they wait in the stands before the scheduled start of Ohtani in a baseball game against the Seattle Mariners,, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels’ Mike Trout hits a three-run home run against the Seattle Mariners in the sixth inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels’ Mike Trout watches his three-run home run against the Seattle Mariners in the sixth inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Seattle Mariners’ Ben Gamel, left, slides into third base as Los Angeles Angels third baseman Zack Cozart (7) reaches for the throw in the fifth inning of a baseball game, Sunday, May 6, 2018, in Seattle. Gamel was ruled out after a video review of the play on the tag from Cozart after Gamel came up off the bag. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani, right, walks off the mound after he was pulled from a baseball game against the Seattle Mariners during the seventh inning, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani throws against the Seattle Mariners as smoke from fireworks that were launched when Mariners’ Ryon Healy hit a two-run home run hangs in the air at Safeco Field during the seventh inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Seattle Mariners starting pitcher Felix Hernandez, right, stands near the mound as Los Angeles Angels’ Rene Rivera runs to first base after hitting an RBI-single in the sixth inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels outfielders Chris Young, left, Mike Trout, center, and Jabari Blash, right, greet each other at the end of a baseball game against the Seattle Mariners, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels starting pitcher Shohei Ohtani walks away from a postgame TV interview with his shoulder and elbow taped after he earned a win in the Angels’ victory over the Seattle Mariners in a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)Los Angeles Angels’ Chris Young is greeted in the dugout after he hit a solo home run during the second inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)NextShow Caption1 of 20Los Angeles Angels’ Chris Young is greeted in the dugout after he hit a solo home run during the second inning of a baseball game, Sunday, May 6, 2018, in Seattle. (AP Photo/Ted S. Warren)ExpandSEATTLE — Fans at Safeco Field greeted Shohei Ohtani with boos when he first stepped on the field on Friday and when he stepped off for the last time on Sunday.In between, he gave them good reason to lament that he’s not wearing their team’s uniform.Ohtani took a shutout into the seventh inning of the Angels’ 8-2 victory over the Mariners on Sunday afternoon, after collecting two hits in the series opener on Friday.With the help of Mike Trout, whose three-run homer was one of nine hits in the weekend, the Angels won for the fifth time in their past six games. Angels offense breaks out to split doubleheader with Astros The Mariners, however, are accustomed to watching Trout do amazing things. This weekend was their first chance during the regular season to see see Ohtani.Sign up for Home Turf and get 3 exclusive stories every SoCal sports fan must read, sent daily. Subscribe here.He showed his talent with the bat and on the mound, which is why just about every team in the majors wanted Ohtani. The Mariners were considered one of the favorites before he surprised much of the baseball world by picking the Angels.“I want to pitch well against not just this team, but every other team that was pursuing me, to show them that they weren’t wrong with their scouting,” Ohtani said through his interpreter. Newsroom GuidelinesNews TipsContact UsReport an Errorlast_img read more

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Kevin Durant injury update: Warriors F (ankle) will not play vs. Rockets

first_imgHe missed practice Tuesday and is officially listed as day-to-day.Kevin Durant didn’t practice in Houston tonight. Will not play vs Rockets tomorrow.— Anthony Slater (@anthonyVslater) March 12, 2019Kevin Durant officially day-to-day with the sprained ankle. No word on his status Saturday at Thunder, the Warriors lone trip to OKC this season. https://t.co/J8zNJudFT8— Anthony Slater (@anthonyVslater) March 12, 2019The Warriors’ playoff spot is all but set in stone at this point, so Durant missing this contest isn’t the worst thing for the top seed in the Western Conference. Related News Warriors coach Steve Kerr: Kevin Durant will be ‘alright’ However, this marks the second straight game between the two squads a former MVP has been ruled out.James Harden missed Houston’s 118-112 win over the Warriors on Feb. 23 with a cervical strain and flu-like symptoms. In a preview of what could be a playoff matchup between the Rockets and Warriors on Wednesday, one key player will be out.Kevin Durant, who rolled his ankle in a loss to the Suns on Sunday, will not play in the game.center_img Charles Barkley sounds off again on Kyrie Irving, Kevin Durant The Rockets come into the matchup with a 42-25 record. Golden State is 45-21.Durant’s status for the Warriors’ games against the Thunder this weekend is unclear.last_img read more

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