Eight drown while clicking selfies on boat

first_imgEight persons who were enjoying a boat ride in the Vena reservoir near Nagpur on Sunday, drowned when they tried to take a selfie. One of the victims, Pankaj Doifode, 25, was live on Facebook along with his seven friends. “Majjani life. Panike bich me” (Enjoying life right at the centre of the reservoir),” one of them could be seen shouting in the Facebook video.The boat carrying Pankaj, his seven friends and three villagers who had provided them the boat, capsized minutes after the video was posted on the Facebook. “Of the 11 people on the boat, eight drowned. Three swam to safety. The accident seems to have happened when the young men came on one side of the boat to click selfies and videos which tilted the boat. They were busy clicking photos and videos that they overlooked the water that was entering their boat. Some of them were under the influence of alcohol. We have recovered seven bodies and search is on for one body,” police inspector Chandrashekhar Bahadure, who was supervising the search, told The Hindu.last_img read more

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Porzingis scores 30, Knicks beat Nets for 1st win

first_imgNew York Knicks forward Kristaps Porzingis (6) drives the lane against Brooklyn Nets forward Quincy Acy (13) during the second quarter of an NBA basketball game, Friday, Oct. 27, 2017, in New York. (AP Photo/Julie Jacobson)NEW YORK — Frank Ntilikina and the New York Knicks both got on the board Friday night.The rookie guard scored his first NBA points, and the Knicks beat the Brooklyn Nets 107-86 for their first victory of the season.ADVERTISEMENT Read Next Typhoon Kammuri accelerates, gains strength en route to PH QC cops nab robbery gang leader, cohort Don’t miss out on the latest news and information. Brace for potentially devastating typhoon approaching PH – NDRRMC Federer into Swiss Indoors semis; Del Potro to play Cilic “We’re not surprised because we see it every day in practice,” Hornacek said.Ntilikina, who missed the previous two games with a sprained left ankle after a scoreless NBA debut, made a long jumper with 49 seconds left in the third quarter. The French guard hit a 3-pointer early in the fourth and also had five assists.Russell got the first basket of the third quarter to cut New York’s lead to three, but the Knicks controlled the next seven minutes of play. Porzingis had a follow dunk and three-point play as he and Kanter combined for all the points in a 9-0 run. Soon after, a 12-2 spurt extended the lead to 72-50.TIP-INSNets: Brooklyn missed its chance to even the all-time series, which the Knicks lead 95-93. … Russell was the only Nets starter in double figures.Knicks: Willy Hernangomez, an All-Rookie selection last season who had played just 15 minutes in the first three games — sitting out one entirely — got in during the first half and finished with four points. … It was the Knicks’ most lopsided victory since beating Phoenix 128-97 on March 9, 2016. Their largest win last season was 16 points.BACKBOARD BEATINGThe Knicks outrebounded the Nets 55-34, racking up a 31-6 edge in second-chance points. “They played harder than us. They killed us on second-chance points,” swingman Allen Crabbe said. “You’re just not giving yourself a chance.”BROOKLYN BUYERJoseph Tsai, the executive vice president of the Alibaba Group, a Chinese e-commerce company, has agreed to purchase a 49 percent stake of the Nets from Russian billionaire Mikhail Prokhorov , with the option to become controlling owner in four years, a person with knowledge of the details told The Associated Press on Friday. Prokhorov, who bought the team in 2010 and oversaw its move from New Jersey to Brooklyn, will eventually become the minority owner, retaining 20 percent of the franchise after Tsai takes control in 2021. CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Kammuri turning to super typhoon less likely but possible — Pagasacenter_img Kin of Misamis Oriental hero cop to get death benefits, award — PNP LATEST STORIES UP NEXTNets: Host Denver on Sunday.Knicks: Visit Cleveland on Sunday. MOST READ Stronger peso trims PH debt value to P7.9 trillion “It was important because obviously it was our first win, but I think the most important thing in all of these three losses, we stick together,” center Enes Kanter said. “We stick together in every practice, we practice really hard and then tonight it was all about defense and we did a great job.”D’Angelo Russell returned from a one-game absence with 15 points for the Nets, who looked nothing like the team that beat Eastern Conference champion Cleveland two nights earlier.They came in averaging 121.2 points and had reached 110 in each of their first five games, but shot just 40.5 percent from the field against their city rivals.“They were the more energetic team,” Nets coach Kenny Atkinson said. “They were the more physical team. They were denying us left and right. We couldn’t handle their pressure. We were lethargic and we paid for it.”Knicks coach Jeff Hornacek gave veteran Jarrett Jack his first start at point guard and he responded with eight points, seven rebounds and five assists. Ntilikina, who has been injured for much of the time since former president Phil Jackson made him the No. 8 overall draft pick, then picked up the backup minutes and played well.ADVERTISEMENT “It was great. We had a great game and I think the fans liked it,” Ntilikina said.Kristaps Porzingis had 30 points and nine rebounds, and Ntilikina finished with nine points as the Knicks became the last team in the league to get a win this season.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutThey did it with a surprisingly strong defensive effort that shut down the NBA’s highest-scoring team, holding the Nets about 35 points below their average.New York blew it open with a 25-6 run in the third quarter that turned a three-point lead into a 72-50 cushion and coasted from there after three straight losses that followed a winless preseason. Japan ex-PM Nakasone who boosted ties with US dies at 101 View commentslast_img read more

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10 months agoBrighton winger Locadia delighted to prove matchwinner

first_imgBrighton winger Locadia delighted to prove matchwinnerby Paul Vegas10 months agoSend to a friendShare the loveBrighton winger Jurgen Locadia was delighted to prove the matchwinner for victory over Everton.The Dutchman claimed his second goal in two games.He said, “It’s crazy, I’ve gone from not playing every game to then scoring two games in a row. I’m very happy and proud and I want to thank everybody for reaching this moment.“We started well in the first half and also began the second half well too. Everton created a lot of chances, and they almost scored, but I feel that we deserved the win today.“For the goal, I saw the ball deflect off an Everton player and it was a clear goal in my opinion, but the referee had his doubts. In the end, he gave it.” About the authorPaul VegasShare the loveHave your saylast_img read more

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10 months agoCrystal Palace boss Hodgson: I’d welcome new striker

first_imgCrystal Palace boss Hodgson: I’d welcome new strikerby Paul Vegas10 months agoSend to a friendShare the loveCrystal Palace boss Roy Hodgson has opened the door to signing a new striker in January.Hodgson was asked about his market plans after victory over Wolves.He said, “We’ve got a man coming back we hope. Benteke trains with us tomorrow and obviously he’ll be fully back with us in the course of the next week. If he gets match fit then that will be to an extent a new signing this year because we’ve hardly seen him.“If there are other players that the club can bring in, I certainly won’t be averse to that because we have a very small squad and we haven’t had a lot to back us up at the minute. We’re on the lookout of course and the chairman and technical director are anxious to do what they can to give me and my coaching staff more support, but it’s not easy certainly when you have limited transfer resources.” TagsTransfersAbout the authorPaul VegasShare the loveHave your saylast_img read more

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a month agoLiverpool defender Van Dijk: I belong on the dais with Messi and Ronaldo

first_imgAbout the authorPaul VegasShare the loveHave your say Liverpool defender Van Dijk: I belong on the dais with Messi and Ronaldoby Paul Vegasa month agoSend to a friendShare the loveLiverpool defender Virgil van Dijk insists any individual awards “won’t change me”.Van Dijk won UEFA’s Player of the Year at the end of last month, being awarded the title ahead of football greats Lionel Messi, of Barcelona, and Juventus striker Cristiano Ronaldo.After helping Liverpool win the Champions League last season and finish runners up to Manchester City in the Premier League title race, Van Dijk is also up for FIFA’s The Best gong. And again among the nominees are Messi and Ronaldo.Van Dijk, who also won last season’s PFA Player of the Year, told Algemeen Dagblad: “Whatever comes out, it won’t change me.“Look, you can’t compare me as a football player with (Lionel) Messi or (Cristiano) Ronaldo. I think the only thing you can try is to compare the impact we have had on our teams. And even that is very difficult.”I am especially pleased that there is appreciation for defenders. That we are being looked at differently. And that there can be a reward for all the dirty work that has been done.”Van Dijk is quick to highlight the contribution of teammates to his success – both with Liverpool and The Netherlands. The defender, who kicked off his career with Willem II ten years ago, admits the individual recognition is reliant on winning trophies with his team.He added, “This is thanks to the boys from Liverpool and Oranje. You really only win these prizes if you have achieved success together.”No matter what happens, Van Dijk insists he will accept the title proudly should he win The Best trophy.He explained: “Do I deserve it? What I think is that we have had a fantastic year. We were also able to win the Super Cup back in August. It just feels great. A defender does not often win individual prizes. I think Fabio Cannavaro was the last in 2006. Maybe it is time for a defender again.”- updated September 23 last_img read more

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14 days agoSampdoria defender Julian Chabot scouted by Everton

first_imgSampdoria defender Julian Chabot scouted by Evertonby Carlos Volcano14 days agoSend to a friendShare the loveSampdoria defender Julian Chabot is being watched by Everton.TMW says Everton had scouts posted at the Estadio Nuevo Arcangel in Cordova, where they checked on Chabot in action for Germany U21 against Spain. The defender was outstanding in the friendly, outshining Spain star Dani Olmo, of Dinamo Zagreb.Chabot only moved to Samp in May from Groningen for €3.7m.The defender is viewed at Samp as a long-term centre-half. TagsTransfersAbout the authorCarlos VolcanoShare the loveHave your saylast_img read more

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4-Star WR Equanimeous St. Brown Spoke 3 Languages During His Announcement To Notre Dame

first_imgA general view of Notre Dame's football field.SOUTH BEND, IN – SEPTEMBER 25: A general view of the opening kick-off between the Notre Dame Fighting Irish and the Stanford Cardinal at Notre Dame Stadium on September 25, 2010 in South Bend, Indiana. Stanford defeated Notre Dame 37-14. (Photo by Jonathan Daniel/Getty Images)Anaheim (Calif.) Servite four-star wide receiver Equanimeous St. Brown committed to Notre Dame this afternoon, and he showed off being trilingual in the process of doing it. St. Brown’s mother is from Germany, and he spent time attending school in France. He began his announcement and made his commitment in English, but dropped some German and French in between.Here’s St. Brown thanking his mother in German: So St. Brown speaks three languages, his father is a former Mr. World and Mr. Universe bodybuilder and his name is derived from the word equanimity, meaning “mental calmness, composure, and evenness of temper, especially in a difficult situation.” Oh, and he has younger brothers named Osiris and Amon-Ra. He just may be the Most Interesting Recruit In The World.last_img read more

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Photos: Honeymooners Sporting Their Tux And Wedding Dress Are At Kentucky’s Game vs. South Carolina

first_imgHoneymooners in wedding tux and dress at Kentucky vs. South Carolina.It’s Valentine’s Day, so it’s fairly fitting that a recently married couple is attending Kentucky’s game against South Carolina at Rupp Arena this afternoon. The couple, which got married Friday night, is sitting in the upper section of the Wildcats’ arena, with the groom sporting his tuxedo and the bride still wearing her wedding dress. Check it out: Here’s our new favorite honeymooners sitting 1st row upper arena @Rupp_Arena after getting married last night pic.twitter.com/v6k9s9Bea5— Ryan Lemond (@ryanlemond) February 14, 2015There’s a bride at Rupp Arena today: pic.twitter.com/hmWR6RHcPx— Ashley Scoby (@AshleyScoby) February 14, 2015How grand is UK basketball? These fine Kentucky folks were just married in the Commonwealth’s church, Rupp Arena. #fb pic.twitter.com/1QwZNQMDOc— Benjamin Riggs (@bpriggs) February 14, 2015Woman in wedding dress watching basketball in second level of Rupp Arena. (Above A in Whitaker). pic.twitter.com/ZhmxF36x6Z— Brian Bennett (@BennettESPN) February 14, 2015Love and Basketball combine @Rupp_Arena for @KentuckyMBB vs South Carolina. #BBN #Bluelyweds pic.twitter.com/Na3HgVOs1C— KYwildcatsTV (@KYwildcatsTV) February 14, 2015Basketball, clearly, reigns supreme in the Bluegrass State. Kentucky and South Carolina are currently playing on ESPN.last_img read more

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Rep Hank Vaupel Weekly Column August 27 2018

first_img Categories: Vaupel News 27Aug Rep. Hank Vaupel Weekly Column: August 27, 2018 As many of you know, “The Wall That Heals” is a mobile, 80% scale replica of the Vietnam Veterans Memorial Wall in Washington D.C. and is currently touring the country. It is an important way for veterans, family, and citizens to remember and honor those who gave their all in the Vietnam War and to all those who have sacrificed for their country. Along with the more than 58,000 names commemorated on the Wall, the exhibit includes an educational center, personal and historical artifacts, and information about those listed on the Wall.“The Wall That Heals” is currently visiting Livingston County as its only stop in Michigan during its nationwide tour. It arrived on Tuesday with a full motorcycle escort from Cabela’s in Dundee to the Spencer J. Hardy Airport in Howell where it was set up on Wednesday. I was honored to welcome volunteers and supporters of the Wall as it arrived and to participate in the wreath-laying ceremony on Thursday. Seeing the Wall and taking part in the ceremonies was very moving. If you have not already done so, then I encourage everyone to visit the Wall and honor those who have given their lives for our freedoms. Thank you to the many people involved whose hard work gave us this opportunity. The Wall will be on display through Sunday, August 26th.***I have attended several meetings over the past week to provide updates and ideas on current issues facing the state. On Tuesday, I joined state Sen. Joe Hune and fellow state Rep. Lana Theis at the Hartland Township monthly board meeting to discuss property tax legislation currently being considered by the Legislature.Sen. Hune, Rep. Theis, and I also participated in a roundtable hosted by Congressman Mike Bishop on the topic of opioid drugs being shipped directly to patients. The continuing epidemic of opioid abuse is not something we can take lying down. Thank you Congressman Bishop for organizing and leading this discussion.***Congratulations to the Howell Area Parks & Recreation Authority and all the volunteers and organizations involved in making this year’s Howell Melon Festival another great success! The Melon Fest is a tribute to Howell’s community spirit and a perfect way to show off the success of downtown. I look forward to continuing this great Livingston tradition!***I wanted to take a moment to recognize a couple outstanding local residents. Guy Houseman is a 26-year employee at Consumers Energy’s Howell service center. On July 3, he responded to a house fire on Coon Lake Road to shut off the natural gas. After arriving and securing the gas, Mr. Houseman remembered visiting the house previously and knew there was a dog inside. He notified the firefighters who were able to save the 12-year-old beagle without injury. Thank you for your selfless commitment to your community and neighbors!I would also like to congratulate Howell resident and Michigan’s official Troubadour Neil Woodward on receiving the 2018 Michigan Heritage Award from the Michigan Traditional Arts Program of the MSU Museum. Mr. Woodward has dedicated over 30 years to researching, arranging, and sharing folk music, and he has traveled the state sharing his talents. This award is just the most recent of his many accolades, and we are proud of all he has accomplished!***If you have any ideas, comments or questions for my office, please do not hesitate to call us at 517-373-8835 or send an email to HankVaupel@house.mi.gov. We are happy to hear from you!PHOTO INFORMATION: State Rep. Hank Vaupel greets volunteer John Church during the Howell Melon Fest.last_img read more

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Lithuanian cable operator CGates has acquired smal

first_imgLithuanian cable operator CGates has acquired smaller operator Transteleservis, which operates TV and broadband services in the towns of Visaginas and Pabradé.The move expands CGates’ consumer base by about 7,000, taking its total to 270,000 across the country. Terms of the transaction were not disclosed.CGates’ chief executive, Petras Kirdeika, said that the integration of Transteleservis would begin in the near future. He said that CGates would continue to consolidate smaller operators across the country, following last year’s acquisition of Remo TV and TPG.CGates is itself being decoupled from Estonia’s Starman Group, its previous owner, following a deal at the end of last year that saw Finnish group Elisa take over Starman’s Estonian assets for €151 million.Elisa’s acquisition of Starman from Polaris Invest and Com Holding, following the divestment to the latter of its majority stake by previous controlling shareholder East Capital Explorer, left CGates in the hands of the two investment groups. The pair said they would continue CGates’ strategy of consolidating the Lithuanian cable market.last_img read more

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NBC Entertainment cochairmen George Cheeks and Pa

first_imgNBC Entertainment co-chairmen George Cheeks and Paul Telegdy have said that the business’s planned streaming service will require a “reinvention” of windowing that will affect its content strategy going forward.The newly appointed co-chairmen, who have been in the roles for four months following the exit of Bob Greenblatt, told NATPE Miami delegates that NBC has been “very thoughtful” in how it enters the OTT space, and will mimic the Hulu model of serving as both an AVOD and SVOD proposition.“We believe Netflix-chasing is not a strategy, so we feel excited and bullish about where this is headed,” said Cheeks, noting that there “isn’t a one-size-fits-all strategy”.NBCUniversal revealed last week that a new OTT platform is to be made available to subscribers of NBCUniversal parent group Comcast, as well as European pay-TV operator Sky, which was acquired last year.The ad-supported, free service, which will reach around 52m subscribers in total, is to feature original content as well as third-party programming. Meanwhile, an ad-free version of the service, that will be priced competitively, is also in the works, while non-Comcast or Sky subscribers will be given the chance to sign up to the service separately.“One possibility is you take all your originals and all your licenses – once the cycle is off – and put them all in one ecosystem,” said Cheeks, assuring that the NBCU service will be a “bit more nuanced and bespoke”.“We will look at every original production and every licensed show that cycles off and decide where it belongs. It might be that it belongs exclusively within our ecosystem or it might be that it belongs exclusively on an outside ecosystem or there might be an in-between.”On the back of controversial deals such as Netflix and WarnerMedia’s Friends renewal, there has been widespread speculation around what might happen to The Office, which is one of Netflix’s top shows but is set to expire in 2021, leaving NBCU to decide whether the content might live on its fledgling platform or Netflix.Cheeks noted that seeing The Office in Netflix’s top show rankings is “gratifying”.“What consistently blows me away is that The Office has been on Netflix for 10 years and it is still consistently in their top five. As for where it goes next, we have to ask ourselves that question. The Netflix license runs for a couple of years and we’ll have to see where that goes.”Netflix’s VP of acquisitions Amy Reinhard told TBI earlier this week that the platform would “absolutely be in those negotiations” for the show.Talent relationshipsAsked how NBCU is looking to keep up with cash-flush SVODs and their major talent deals, Telegdy appeared bullish, noting that “people can talk to producers who have had long-term, repeat business with us as studio and rights exploitation business, and [they will say] it’s a partnership.“It can feel like we’re a rights acquisitive company but that’s because we believe in maximising revenues for producers. I would partner with us if you want big checks over a long period of time.”One recent talent partner is singer Kelly Clarkson, who fronts a new syndicated daytime talkshow for NBCU called The Kelly Clarkson Show. The star was in town in Miami on Tuesday (22 January) evening, performing at an intimate venue for various buyers.“It’s a really hard job because of the number of episodes required,” explained Telegdy.“We need someone who meets you with right kind of energy and work ethic. We’d seen her over the years as someone who could put a bright face on at 7am, and she showed up with incredible energy and attitude.”last_img read more

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SD MEPs elect Iratxe García Pérez as new Group President

first_imgCongratulations @IratxeGarper on your election as our new president @TheProgressives! I look forward to build a better, fairer, more social and sustainable Europe with our new team.— Kathleen Van Brempt (@kvanbrempt) June 18, 2019 Iratxe García PérezIratxe García Pérez MEPs from the Socialist and Democratic Group in the European Parliament have selected Iratxe García Pérez as their new Group President today.The Spanish MEP of the Spanish Socialist Worker’s Party was the only eligible candidate to stand in time for today’s election.Our new President: @IratxeGarper pic.twitter.com/7Hx1SDyjhC— S&D Group (@TheProgressives) June 18, 2019S&D MEPs were asked to vote at 3PM this afternoon.The decision came after the former President Udo Bullmann who was expected to seek another term, decided to bow out of the race on Monday.In his letter to S&D MEPs Bullmann encouraged his colleagues to continue the push to be the guiding platform in Europe, ‘internationalism must become an even stronger lighthouse for our actions, no matter where we sit.’My warmest congratulations! @strankaSD https://t.co/xOmxswQSPN— Tanja Fajon, mag. (@tfajon) June 18, 2019 Huge congratulations to @IratxeGarper – newly elected as @TheProgressives Group President.She delivers a powerful speech vowing to take on the far-right and the populists who would build divisions between us. pic.twitter.com/iJ4dmTtd53— Seb Dance MEP (@SebDance) June 18, 2019WhatsApp SharePrint <a href=’http://revive.newsbook.com.mt/www/delivery/ck.php?n=ab2c8853&amp;cb={random}’ target=’_blank’><img src=’https://revive.newsbook.com.mt/www/delivery/avw.php?zoneid=97&amp;cb={random}&amp;n=ab2c8853&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a>last_img read more

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Curacity Announces Dwell Partnership

first_imgDesign-focused publisher taps Curacity for Omni-Channel Revenue Attribution Measurement and Monetization of their Forthcoming Editorial Content on HotelsCuracity, a data analytics company serving the hotel industry, announced its partnership with Dwell, a publisher reaching architects, designers and enthusiasts. Dwell will be expanding its already robust content offerings to write about well-designed hotels thanks to this partnership with Curacity, whose end-to-end content measurement and monetization platform unlocks previously unattainable revenue to publishers.Dwell will write about the hotels their editorial team wishes to write about. With its proprietary data technology, Curacity identifies consumers that book a hotel up to twelve months after engaging with Dwell hotel editorial content, and converts that into commissions for Dwell. Unlike outdated last-click methodologies, affiliate programs, and cookie-tracking, Curacity technology will enable Dwell to measure the full financial impact of their content in a way that drives incremental, scalable revenue. On average, publishers who have been working with Curacity for one year have tripled their hotel editorial coverage.Marketing Technology News: Smartsheet Announces General Availability of Smartsheet Gov at AWS Public Sector Summit“Curacity is excited to partner with Dwell, as they are a leader in discovering and writing about outstanding design,” said Nick Slavin, President and Co-founder of Curacity. “Our product suite creates a first-of-its-kind financial feedback loop for publishers and hotels. We are thrilled that Dwell is investing more heavily in hotel content because we can measure, monetize, and drive hotel commissions to the source, like Dwell, that built the demand for the hotel booking. Simultaneously, this turns Dwell’s hotel content into a distribution channel for the hotels being featured.”Marketing Technology News: LiveData Announces the Launch of PeriOp Manager for Salesforce Health Cloud on Salesforce AppExchange“Dwell is a long established home design magazine that successfully moved into the digital age, and our partnership with Curacity continues our brand’s innovation,” said CFO of Dwell, Nicole Wolfgram. “Being able to seamlessly measure how our editorial coverage converts to commerce is a game changer for any publisher or editor.”Marketing Technology News: Political Marketers Spent 60% of Digital Ad Budgets on Programmatic Buying in 2018 US Midterms Curacity Announces Dwell Partnership PRNewswireJune 11, 2019, 4:23 pmJune 11, 2019 Curacitydata analyticsDwellNewsPartnership Previous ArticleHow to Create a Customer-Centric Strategy for Your BusinessNext ArticleZapier’s Apps at Work Report Highlights the Fastest Growing Appslast_img read more

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Lower BMI before obesity surgery predicts greater postoperative weight loss study finds

first_img Source:http://www.uef.fi/-/outcomes-of-weight-loss-surgery-can-be-improved Reviewed by James Ives, M.Psych. (Editor)Dec 11 2018Lower BMI before bariatric surgery predicts greater post-operative weight loss, a new study from the University of Eastern Finland finds.”Patients should definitely be encouraged to lose some weight already before their obesity surgery. This leads to a better weight management outcome in the future,” says Clinical Lecturer Pirjo Käkelä, Lic.Med., from the University of Eastern Finland, presenting the findings in her PhD thesis.The study also found that small intestinal length is associated with serum triglyceride levels both before and after bariatric surgery. This means that it is possible to influence blood lipid levels by adjusting the length of the bypassed small intestine during obesity surgery.Moreover, patients with gallbladder disease have lower serum plant sterol levels than others, and this is independent of post-operative weight loss, duration of gallbladder disease and non-alcoholic fatty liver disease.”Because these factors did not play a role, the lower plant sterol levels in patients with gallbladder disease can probably be explained by their potentially inherited alterations in sterol absorption and biliary transport.”The study is based on extensive data covering nearly 500 well-characterized bariatric patients who were recruited to the Kuopio Obesity Study (KOBS) in 2005-2015, as well as nearly 1,600 symptomatic gallstone patients who underwent laparoscopic cholecystectomy in a Finnish central hospital in 1995-2008. The bariatric procedure used was laparoscopic gastric bypass.Increasing demand for bariatric surgery Bariatric surgery is an excellent treatment for severely obese patients. In Finland, approximately 80% of all bariatric operations are laparoscopic gastric bypasses. It is estimated that at least 3,000 patients in Finland need bariatric surgery every year. However, the number of bariatric operations performed has stabilized at around 1,000 surgeries per year.Gallstones can cause symptoms after bariatric surgery Related StoriesBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryLow-carb diet may reverse metabolic syndrome independent of weight lossUNC receives $3.8 million grant to assess impact of Med-South behavioral weight loss programThe rising prevalence of gallstone disease in western countries has been associated with increasing prevalence of obesity and rapid weight loss induced by bariatric surgery. Furthermore, asymptomatic gallstones may become symptomatic and induce cholecystitis, and possibly lead to cholecystectomy.Small intestinal length associates with triglycerides The findings of the study suggest that small intestinal length is not associated with post-operative weight loss. However, small intestinal length is associated with serum triglyceride levels both before and after bariatric surgery. According to Clinical Lecturer Käkelä, this association with lipid metabolism suggests that it is worthwhile to measure the whole small intestinal length during the bariatric operation, which is something that isn’t routinely done.”We suggest that the length of the total small intestine should be measured routinely during a bariatric operation, with special consideration given to the ratio of the bypassed lengths. This way, the outcomes of bariatric surgery could be even better with regard to comorbidities.”Cholecystectomy is safe for obese patients Lower BMI before bariatric surgery predicts greater post-operative weight loss. Obesity and comorbidities did not increase the risk of complications after cholecystectomy. However, in symptomatic gallbladder disease, comorbidities increased the prevalence of open surgery. Nevertheless, cholecystectomy was established as safe also for obese individuals.Patients with gallbladder disease had the lowest serum plant sterol levels independent of post-operative weight loss, duration of gallbladder disease and non-alcoholic fatty liver disease, which suggests potentially inherited alterations in sterol absorption and biliary transport.Genetic factors, together with environmental factors, are known to have an influence on weight regulation. However, the genetic risk score was not a predictor of post-operative weight loss.last_img read more

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New link found between NAFLD and rare pregnancy complication

first_img Source:https://ddw.org/home Reviewed by James Ives, M.Psych. (Editor)May 9 2019A new link has been found between a rare and serious condition that typically presents as itchy palms during pregnancy and the world’s most common chronic liver disease, according to research presented at Digestive Disease Week® (DDW) 2019. Researchers found that intrahepatic cholestasis of pregnancy (ICP), a bile acid disorder in adults that affects roughly one of every 300 pregnancies, may be associated with non-alcoholic fatty liver disease (NAFLD).”Intrahepatic cholestasis of pregnancy is characterized by build-up of bile acids during pregnancy and is associated with an increased risk of fetal death if left untreated,” said co-author Erica Monrose, MD, of the Icahn School of Medicine at Mount Sinai, New York, New York. “NAFLD, on the other hand, has been linked with the dysregulation of bile acids, but their role is not well understood. Our research shows that there is a connection between impaired bile acid metabolism in both disease processes, which could have implications for future management of NAFLD.”Related StoriesPregnant women with migraine more often have complications during pregnancy and childbirthData collected by ESHRE show rise in use of IVF in infertility treatmentCannabis use during pregnancy may cause premature birthThe study looked at medical records of 149 pregnancies complicated by ICP among a largely Latina population, one of three ethnic groups, along with Bengali and Swedish women, most often found with ICP. Researchers compared ICP pregnancies to a control group of 200 women, through liver imaging and other criteria. They found that women with ICP were 5.7 times more likely to have a diagnosis of fatty liver disease than patients in the control group.”In the search for therapeutic drugs for NAFLD, scientists need a better understanding of the role bile acids play in NAFLD disease progression,” Dr. Monrose said. “If the connection is confirmed, ICP may prove a novel model through which to investigate bile acid metabolism in patients with NAFLD.”In the U.S. alone, NAFLD, which is often treated by changes in diet, affects an estimated 80 to 100 million people and has become the second-leading cause of liver transplant, and the leading cause among women.”In addition to helping solve the mystery of NAFLD, our study also suggests that ICP patients should be seen by a liver specialist because they may go on to develop chronic liver disease,” said Dr. Monrose.Given these findings, additional research should look at differences in NAFLD progression in women who had NAFLD and were later diagnosed with ICP, compared to women with NAFLD who did not go on to develop ICP. Additionally, as bile acids have been implicated in the progression of NAFLD, future research should investigate possible differences in NAFLD progression between ICP patients and their counterparts. Finally, patients with NAFLD who develop ICP may benefit most from drugs being developed that target the bile acid metabolism pathways.DDW Presentation DetailsDr. Monrose will present data from the study, “Intrahepatic Cholestasis of Pregnancy (ICP) is associated with higher prevalence of NAFLD: A case-control study,” abstract Sa1562, on Saturday May 18 at noon PDT.last_img read more

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Researchers identify why lymphoma patients may become resistant to specific drug

first_imgSource:H. Lee Moffitt Cancer Center & Research InstituteJournal reference:Tao, J. et al. (2019) BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. doi.org/10.1016/j.ccell.2019.04.005. Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerNew protein target for deadly ovarian cancerChaos in the house and asthma in children – the connectionThe transcriptional reprogramming was dependent on a protein called CDK7. These observations suggested that targeting CDK7 may be an effective strategy to prevent Venetoclax resistance. The researchers conducted a chemical screening of a set of small molecule inhibitors further confirmed this hypothesis by showing that combination treatment with ABT-199 and the CDK7-targeting inhibitor THZ1 prevented the emergence and maintenance of ABT-199 resistance in models of MCL and DHL. The patient samples assessment further proved the clinical relevance of this study, which can unveil the drug resistance mechanism in patient care in the future. Disabling CDK7 in combination with ABT-199 is an attractive means to provoke tumor regression of otherwise refractory lymphoma, and such a combination strategy could be applied across a broad spectrum of hematological malignancies”Jun Qi, Ph.D., assistant professor in medicine at the Department of Cancer Biology Dana-Farber Cancer Institute and Harvard Medical School Certain regions of the DNA called super-enhancers became activated or deactivated in the resistant cells, leading to either a downstream loss or gain in protein expression, which ultimately contributed to cell survival. The study, for the first time, unified genetic alteration and non-genetic adaptive response as a driving force for drug resistance evolution to therapy”Jianguo Tao, M.D., Ph.D, senior member of the Department of Laboratory Medicine and Hematopathology at Moffitt Cancer Center Reviewed by James Ives, M.Psych. (Editor)May 16 2019With more targeted therapies being approved each year for cancer, the development of drug resistance to these agents is a growing concern. It has often been assumed that drug resistance is due to the presence or development of additional genetic alterations; however, it is now clear that resistance mechanisms are more complicated.Researchers from Moffitt Cancer Center and Dana-Farber Cancer Institute have discovered a mechanism of drug resistance to Venetoclax®, also known as ABT-199, a BCL-2 targeting drug commonly used to treat chronic lymphocytic leukemia and acute myeloid leukemia. Their findings, published in the journal Cancer Cell, also suggest a possible co-treatment strategy to overcome this resistance.BCL-2 is a protein that promotes cell survival and is highly deregulated in numerous malignancies. This deregulation can be overcome by treatment with Venetoclax. However, many patients who initially respond to the drug eventually develop resistance and tumor recurrence. The team of researchers led by Jianguo Tao, M.D., Ph.D and Jun Qi, Ph.D., wanted to determine how the BCL2 inhibitor resistance develops in B-cell lymphomas, such as mantle cell lymphoma (MCL) and double-hit lymphoma (DHL), in order to find strategies to overcome and prevent its occurrence.They created model cell lines that were resistant to Venetoclax and compared these cells to the parental cell lines that maintained drug sensitivity. The scientists found that ABT-199 resistance was dependent on both genetic mutations and non-mutational changes. Many patients with hematologic malignancies have an amplification of part of chromosome 18.The researchers discovered that during ABT-199 treatment, rare subpopulations of cells lose this genetic amplification and can survive from drug treatment. Interestingly, this region of chromosome 18 contains the BCL-2 gene, which is the target of ABT-199. This loss of the ABT-199 target and other cell death regulators on chromosome 18 contribute to the survival of these cell populations, which eventually can develop into drug resistance cells.The researchers also demonstrated that the resistant cells developed non-mutational changes involving transcriptional reprogramming.last_img read more

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Supreme Court declines to hear PIL alleging fraud in LICs Jeevan Saral

first_img Press Trust of India  New DelhiJuly 15, 2019UPDATED: July 15, 2019 19:32 IST Senior advocate Arvind Datar said that policy in question has cheated many consumers especially retired persons of their hard-earned money. (File photo)The Supreme Court on Monday refused to entertain an organisation’s plea which alleged that the Life Insurance Corporation (LIC) misled and cheated lakhs of its consumers through its ‘Jeevan Saral’ insurance policy.A bench comprising Chief Justice Ranjan Gogoi and Justice Deepak Gupta took note of the submission of Solicitor General Tushar Mehta, appearing for the the Life Insurance Corporation (LIC), that a PIL under Article 32 of the Constitution should not be entertained as the aggrieved insurance purchaser can approach the consumer courts for redressal of grievances.Tushar Mehta said Life Insurance Corporation (LIC) takes the approval of the Insurance Regulatory and Development Authority of India (IRDAI) before coming out with a policy and there was a mechanism to deal with the grievances.”We are not inclined to hear the public interest litigation (PIL),” the bench said.Senior advocate Arvind Datar, appearing for organization ‘Money Life Foundation’, said that the policy in question has cheated many consumers especially retired persons of their hard-earned money.As per the plea, the proposal form of the scheme did not have any provision to mention the lower maturity sum assured and rather it had a provision only for the higher death benefit.The maturity benefit was not printed on even the policy documents and the customers may get lesser money than the total premium paid, the plea alleged.The organization said that the policyholders were not in a position to raise dispute individually and hence, they came together to form a Non-Governmental Organisation (NGO) to pursue the case.The plea had sought the return of the premium of the policy-holders with 8 percent interest.ALSO READ | Leaving India a big mistake, will return in 24 hours, says IMA Ponzi Scam main accused Mansoor KhanALSO READ | PNB tanks by 10% after another fraud caseALSO WATCH | Nirav Modi scam involving fraudulent LoUs a systemic issue, says Meera SanyalFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShahrukh Tags :Follow LICFollow NGOFollow IRDAI Supreme Court declines to hear PIL alleging fraud in LIC’s Jeevan Saral insurance policySupreme Court on Monday dismissed a plea against LIC Jeevan Saral policy filed by a non-profit organization engaged in promoting financial literacy.advertisement Nextlast_img read more

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Motorists wont be stopped for documents checking if they obey traffic rules

first_imgMotorists won’t be stopped for documents checking if they obey traffic rules: Haryana policeThe Haryana police will not stop motorists for getting their documents checked if they do not “visibly” break any traffic rules, however, vehicle registration would still be checked for prevention of crime.advertisement Next Press Trust of India ChandigarhJuly 11, 2019UPDATED: July 11, 2019 19:56 IST Motorists won’t be stopped for documents checking if they obey traffic ruleMotorists in Haryana will not be stopped for getting their documents checked if they do not “visibly” break any traffic rule, state police chief Manoj Yadava said on Thursday.He said these instructions have been given to all the commissioners of police, inspector general of police traffic and highways and district superintendents of police to stop checking of documents if a vehicle rider has not violated any traffic and road safety rules.The Director-General of Police, however, made it clear that a driver’s license, vehicle registration, among others, would still be checked for prevention of crime and detection measures like sealing of an area after a heinous crime as well as during night patrolling exercises.”Documents would be checked and subsequently challan may also be issued in case any driver is found to have committed any visible traffic violation,” an official release quoting state police chief Manoj Yadava said.”The objective of implementing this novel initiative is to make motorists follow traffic rules, to ensure road safety to the maximum and to curb violations on roads,” he also added.Manoj Yadava said the prime purpose of routine traffic checking is to ensure road safety and to educate and make people aware about having a safe journey.”No unit of the district police, including the traffic, would conduct traffic checks solely for the purpose of ascertaining whether the driver has complete documents. Safe driving by following the traffic rule would also help in preventing road accidents,” State police chief Manoj Yadava said.ALSO READ | Haryana: Doctor shot dead in Karnal, opposition slams BJP govtALSO WATCH | People in 24 villages of Haryana’s Jind drop surnames, embrace village’s nameFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byKritika Kashyap Tags :Follow HaryanaFollow DGPFollow State policeFollow motoristsFollow document verificationFollow Road safetylast_img read more

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